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KMID : 0363320080290020456
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Journal of Korean Oriental Internal Medicine
2008 Volume.29 No. 2 p.456 ~ p.468
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Effects of Gamisagunja-tang in an Ovalbumin(OVA)-Induced Allergic Asthma in Mice
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Son Ji-Woo
Lee Si-Hyeong
Shin Jo-Young
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Abstract
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Objective : The purpose of this study was to investigate the effects of Gamisagunja-tang(GS) on the airway hyper-reactivity (AHR), cytokine production and T cell activation during the ovalbumin (OVA)-induced allergic asthma in mice.
Materials and Methods : BALB/c mice were sensitized and challenged with 100 mg of OVA and 1 mg of aluminum potassium sulfate intraperitoneally on days 1 and 7. On day 14, mice were challenged on 3 consecutive days with 5% OVA. AHR and bronchoalveolar fluid (BALF), total inflammatory cell count and the production of cytokines were measured.
Results : GS significantly suppressed the infiltration of inflammatory cells in the lung tissue and AHR. GS significantly down regulated the production of IL-4, IL-5 and increases of in BALF. GS reduced the population of eosinophils from lung and spleen in OVA-induced allergic asthma. GS reduced the population of T cells in OVA-induced allergic asthma
Conclusion : These results suggest that GS may inhibit the production of IL-4, IL-5 and infiltration of eosinophils and be beneficial oriental medicine for allergic asthma.
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KEYWORD
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Gamisagunja-tang, asthma, cytokines, T cell
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